79821-70-8Relevant academic research and scientific papers
Preparation of optically active ketones
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, (2008/06/13)
An optically active alpha-amino acid derivative having the formula: STR1 wherein: X is OH, Cl, Br, I, or OCOR3 ; Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significant change in symmetry thereof during replacement of X with an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl or alkynaryl radical, or such radical having one or more chemical constituents thereon; and R1 and R2 are different from one another and are each hydrogen or an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl, or alkynaryl radical, or such radical having one or more non-protic chemical constituents thereon is conventionally synthesized from the corresponding alpha-amino acid. The STR2 portion of the above derivative is converted to a ketone functionality without racemization.
