79825-87-9Relevant academic research and scientific papers
Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets
Alford, Benjamin,Baradaran-Heravi, Alireza,Cameron, Scott A.,Clinch, Keith,Gan, Zhonghong,Liu, Hui,Mason, Jennifer M.,Popadynec, Michael,Powell, David A.,Rebollo, Oscar,Rendle, Phillip M.,Roberge, Michel,Whitfield, Dennis M.,Yan, Fengyang,Zubkova, Olga V.
supporting information, p. 1486 - 1492 (2021/08/31)
A significant proportion of genetic disease cases arise from truncation of proteins caused by premature termination codons. In eukaryotic cells some aminoglycosides cause readthrough of premature termination codons during protein translation. Inducing rea
Synthesis of 5-C-Methylated d -Mannose, d -Galactose, l -Gulose, and l -Altrose and Their Structural Elucidation by NMR Spectroscopy
K?llmann, Christoph,Jones, Peter G.,Werz, Daniel B.
supporting information, p. 1220 - 1223 (2018/02/22)
C5/C6-Spirocyclopropanation of exocyclic enol esters followed by alkali ring-opening of the three-membered ring was used for the diastereoselective preparation of 5-C-methylated d-mannose, d-galactose, l-gulose, and l-altrose. Extensive NMR studies demons
BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE
-
Page/Page column 38, (2009/05/29)
The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.
