79834-15-4Relevant academic research and scientific papers
TRISUBSTITUTED BORON-CONTAINING MOLECULES
-
Page/Page column 129, (2011/02/24)
This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.
HSP90 FAMILY PROTEIN INHIBITORS
-
Page/Page column 29, (2010/11/28)
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoic acid derivative represented by General Formula (I): [wherein n represents an integer of 0 to 10; R1 represents substituted or unsubsti
Enantioselective total synthesis of aigialomycin D
Lu, Jiangping,Ma, Junying,Xie, Xingang,Chen, Bo,She, Xuegong,Pan, Xinfu
, p. 1066 - 1073 (2007/10/03)
An efficient, convergent approach for the total synthesis of aigialomycin D 1 is described. Key features of the synthetic strategy include (a) a Sharpless asymmetric epoxidation reaction and selective opening of a 2,3-epoxy alcohol to elaborate the two hy
First total synthesis of two resveratrol derivatives
Su, Ying,Ma, Junying,Peng, Xuanjia,She, Xuegong,Pan, Xinfu,Gao, Jinming
, p. 704 - 705 (2007/10/03)
The total synthesis of two resveratrol derivatives with an isobutyryl substituent is reported for the first time.
Synthetic analogues of the antibiotic pestalone
Kaiser, Florian,Schmalz, Hans-Günther
, p. 7345 - 7355 (2007/10/03)
The first synthetic study towards the natural product pestalone (1) is described culminating in the preparation of selected n-1 analogues. Pestalone is a chlorinated and prenylated benzophenone antibiotic, which is of interest due to a strong activity aga
Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: An efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596
Katoh, Tadashi,Ohmori, Osamu,Iwasaki, Katsuhiko,Inoue, Munenori
, p. 1289 - 1299 (2007/10/03)
An efficient and facile synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone part of Sch 202596 (1) was accomplished in a convergent manner. The synthetic method features (i) a coupling reaction of the aryl aldehyde 6 with the aryl lithium 7 generated in situ from the aryl bromide 8 to deliver the highly substituted diaryl methanol 24 (6+7→24) and ii) oxidative spirocyclization reaction of the benzophenone 4 to construct the requisite spirocoumaranone skeleton [4→(±)-2] as the key steps. The aromatic segments 6 and 8 were prepared from commercially available methyl 3,5-dihydroxybenzoate (9) and 5-methylresorcinol (10), respectively.
Studies toward the total synthesis of Sch 202596, an antagonist of the galanin receptor subtype GalR1: Synthesis of geodin, the spirocoumaranone subunit of Sch 202596
Katoh, Tadashi,Ohmori, Osamu
, p. 465 - 469 (2007/10/03)
An efficient synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone subunit of Sch 202596 (1) was accomplished in a convergent manner by utilizing coupling reaction of the aryl aldehyde 5 with the aryl bromide 6 and oxidative spirocyclization of the benzophenone 4 as the key steps. The aromatic segments 5 and 6 were prepared from commercially available methyl 3,5-dihydroxybenzoate (7) and 5-methylresorcinol (8), respectively.
Methoxymethyl-Directed Aryl Metalation. A Total Synthesis of (+/-)-Averufin
Townsend, Craig A.,Davis, Steven G.,Christensen, Siegfried B.,Link, John C.,Lewis, Charles P.
, p. 6885 - 6888 (2007/10/02)
A total synthesis of (+/-)-averufin, a central intermediate in aflatoxin biosynthesis, is described.The key steps of the synthesis involve the following: (1) the regiospecific coupling of the phthalide anion of 3b and the benzyne derived in situ from aryl
