79837-71-1Relevant academic research and scientific papers
Acylation of Amines with Dichloromaleoyl Chloride
Bonse, Gerhard,Blank, Heinz Ulrich
, p. 1658 - 1664 (2007/10/02)
The reaction of dichloromaleoyl chloride (2) with ammonia in ether yields the ammonium salt of (Z)-2,3-dichloro-3-cyanoacrylic acid (6) and with aqueous ammonia the ammonium salt of (Z)-2-amino-3-chloro-3-cyanoacrylic acid (1).With primary aliphatic and aromatic amines dichloromaleamides 8 are obtained, the two chlorine atoms of which can be replaced with other amines to form after cis/trans isomerization diaminofumaramides 11.
