79844-46-5Relevant academic research and scientific papers
New Synthesis of Diazepam and the Related 1,4-Benzodiazepines by means of Palladium-Catalyzed Carbonylation
Ishikura, Minoru,Mori, Miwako,Ikeda, Toshihito,Terashima, Masanao,Ban, Yoshio
, p. 2456 - 2461 (2007/10/02)
A new synthesis of diazepam (5) was achieved by application of palladium-catalyzed carbonylation to the compound 3 prepared from o-bromoaniline derivative 1 and the amino acid 2, and this procedure was also used for the synthesis of poisonous metabolites
NEW SYNTHESIS OF DIAZEPINONE SKELETON USING PALLADIUM CATALYZED CARBONYLATION
Mori, Miwako,Ishikura, Minoru,Ikeda, Toshihito,Ban, Yoshio
, p. 1491 - 1494 (2007/10/02)
Palladium catalyzed carbonylation to the secondary amine(10) which was easily prepared from N-methyl-2-bromo-4-chloroaniline (1a) and carbobenzyloxyglycine(2a) gave 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione derivative(11) in the yield of 30percent.N-Ace
