79849-46-0Relevant articles and documents
Original electroactive and fluorescent bichromophores based on non-conjugated tetrazine and triphenylamine derivatives: Towards more efficient fluorescent switches
Quinton, Cassandre,Alain-Rizzo, Valérie,Dumas-Verdes, Cécile,Clavier, Gilles,Audebert, Pierre
, p. 49728 - 49738 (2015/06/16)
The synthesis, photophysical and electrochemical properties and their interplay as well as theoretical calculations studies of newly designed fluorescent and electroactive derivatives are described. These molecules are composed of two fluorophores: one triphenylamine, electron-rich unit, and one tetrazine, electron-poor unit, connected by two different links. While in the neutral state the bichromophores are not fluorescent, due to a photoinduced electron transfer from the triphenylamine unit to the tetrazine unit, the fluorescence is restored in the oxidative state (oxidation of the triphenylamine moiety).
Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes: Design, physico-chemical properties and preliminary functional investigations
Hilbold, Beno?t,Perrault, Marie,Ehret, Christophe,Niu, Song-Lin,Frisch, Beno?t,Pécheur, Eve-Isabelle,Bourel-Bonnet, Line
scheme or table, p. 7464 - 7473 (2012/01/06)
Hydrophobic photoaffinity labeling is a powerful strategy to identify hydrophobic segments within molecules, in particular membrane proteins. Here we report the design and synthesis of a novel family of fluorescent and photosensitive lipid tools, which have a common amino acid scaffold functionalized by three groups: (i) a first fatty acid chain grafted with a photoactivatable benzophenone moiety (Fatty Acid BenzoPhenone, FABP), (ii) a second fatty acid chain to ensure anchoring into a half-bilayer or hydrophobic environment, and (iii) a fluorescent carboxytetramethylrhodamine headgroup (CTMR) to detect the photolabeled compound. We present data of the synthesis and characterization of three lipid tools whose benzophenone ring is situated at various distances from the central scaffold. We could therefore establish structure/properties relationships dependent upon the depth of insertion of benzophenone into the membrane. Our lipid tools were extensively characterized both physico- and bio-chemically, and we assessed their functionality in vitro using bacterioRhodopsin (bR). We thus provide the scientific community with novel and reliable tools for the identification and study of hydrophobic regions in proteins.
Silicon-derivates for PET-Imaging
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Page/Page column 14, (2008/06/13)
This invention relates to silicon-derivated compounds suitable for labelling or already labelled with 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).