798552-99-5

Upstream product

• 169526-37-8 (6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one 
• 798552-96-2 2,4-dibromo-5-iodotoluene 
• 625-95-6 3-Iodotoluene 

Downstream Products

• 798552-94-0 1',2'-dideoxy-1'-(2,4-dibromo-5-methylphenyl)-β-D-ribofuranose 
• 798553-00-1 3',5'-O-((1,1,3,3-tetraisopropyl)disiloxane-1,3-diyl)-1',2'-dideoxy-1'-(2,4-diiodo-5-methylphenyl)-β-D-ribofuranose 
• 798552-95-1 1',2'-dideoxy-1'-(2,4-diiodo-5-methylphenyl)-β-D-ribofuranose 

Relevant academic research and scientific papers

Nonpolar thymidine analogs

Nonpolar thymidine analogs are provided comprising a dihalogenated or trihalogenated base of the structure: where R1 is a sugar moiety; R2 is H or CH3; an imaging moiety or a cytotoxic moiety and X1 and X2

A set of nonpolar thymidine nucleoside analogues with gradually increasing size

(Chemical Equation Presented) We describe a series of nonpolar nucleoside analogues having similar shapes and gradually increasing size. The structure of the nucleobase thymine was mimicked with toluene derivatives, replacing 02/04 with hydrogen, fluorine, chlorine, bromine, and iodine. Glycosidic bonds were formed by reactions of lithiated 2,4-dihalotoluenes with a deoxyribonolactone derivative. Structural analysis by NMR showed similar conformations across the series. The compounds are useful for study of the biological recognition of nucleotides and nucleic acids.