798561-06-5Relevant academic research and scientific papers
Purification method of carafine intermediate
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, (2021/10/02)
To 3 - hydroxyacetophenone as a raw material, the intermediate 3 - [1 - (dimethylamino) ethyl] phenol is formed by reaction with dimethylamine, and the intermediate is subjected to resolution and purification by a specific resolution system to obtain S - 3 - [1 - (dimethylamino) ethyl] phenol. Compared with the preparation method of the intermediate prepared by the method, the preparation method has the advantages of low cost, high yield, good effect, less environmental pollution, reduced residue of inorganic salt, and favorability for large-scale industrial production.
Process for the preparation of Rivastigmine
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Page/Page column 5, (2010/11/30)
The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
