79868-24-9

Basic information

• Product Name: (4-tert-butylphenyl)morpholin-4-yl-methanone
• Synonyms: (4-tert-butylphenyl)morpholin-4-yl-methanone
• CAS NO: 79868-24-9
• Molecular Weight: 247.337
• Mol File: 79868-24-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (4-tert-butylphenyl)morpholin-4-yl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-tert-butylphenyl)morpholin-4-yl-methanone(79868-24-9)
• EPA Substance Registry System: (4-tert-butylphenyl)morpholin-4-yl-methanone(79868-24-9)

Safety Data

• Hazardous Substances Data: 79868-24-9(Hazardous Substances Data)

Upstream product

• 1710-98-1 p-tert-butyl benzoyl chloride 
• 110-91-8 morpholine 
• 15226-74-1 dicobalt octacarbonyl 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 201230-82-2 carbon monoxide 
• 36600-66-5 4-tert-butylphenylhydrazine hydrochloride 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 138467-42-2 C₁₇H₁₇NO₃S 

Relevant articles and documents

Tandem Photoredox Catalysis: Enabling Carbonylative Amidation of Aryl and Alkylhalides

We report a new visible-light-mediated carbonylative amidation of aryl, heteroaryl, and alkyl halides. A tandem catalytic cycle of [Ir(ppy)2(dtb-bpy)]+ generates a potent iridium photoreductant through a second catalytic cycle in the presence of DIPEA, which productively engages aryl bromides, iodides, and even chlorides as well as primary, secondary, and tertiary alkyl iodides. The versatile in situ generated catalyst is compatible with aliphatic and aromatic amines, shows high functional-group tolerance, and enables the late-stage amidation of complex natural products.

Green and environment-friendly method for synthesizing amide bonds

The invention provides a green and environment-friendly method for synthesizing amide bonds. The green and environment-friendly method includes forming C-Pd bonds from aryl hydrazine compounds under the oxidation effects of oxygen by the aid of palladium catalysts by means of oxidation hydrazine removal; carrying out carbonyl insertion reaction on the C-Pd bonds and carbon monoxide gas to generate palladium acyl species; feeding primary or secondary amine into palladium acyl and then carrying out reductive elimination to obtain a final product amide. The primary or secondary amine is used as a nucleophilic reagent. The green and environment-friendly method has the advantages that palladium catalytic carboamidation reaction is carried out on the aryl hydrazine compounds, normal-pressure CO is used as a carbonyl source for synthesizing the amide, and byproducts are nitrogen and water which are environmentally friendly; the green and environment-friendly method is novel and environmentally friendly, is high in efficiency and has great potential application value.

Environment-friendly amido bond synthesis method

The invention discloses an environment-friendly amido bond synthesis method, which comprises the following steps: oxidizing an aryl hydrazine compound with O2 to form a C-Pd bond by taking Pd(OAc)2 as a catalyst and taking PPh3 as a ligand, inserting CO to a carbon-palladium bond to form an acyl palladium species as a carbonyl source, attacking carbonyl palladium by virtue of amine as a nucleophilic reagent, and performing reductive elimination to obtain a final product amide. According to the method, synthesis of the amide from the hydrazine compound is implemented by adopting CO as the carbonyl source by virtue of a carbonyl insertion method, and a byproduct does not comprise excessive pollutants such as haloid acid, so that the potential application value can be better achieved.