79871-71-9

Upstream product

• 79838-05-4 4-nitrophenyl-4-morpholinylphosphonochloridate 
• 17327-23-0 2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 
• 777-52-6 1-dichlorophosphoryloxy-4-nitro-benzene 

Downstream Products

• 83894-26-2 Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 4-nitro-phenyl ester 
• 58-97-9 5'-Uridylic Acid 

Relevant academic research and scientific papers

4-nitrophenyl 4-morpholinylphosphonochloridate: a convenient reagent for the synthesis of ribonucleoside mono-, di- and tri-phosphates

The synthesis of the crystalline and easily accessible phosphorylating agent 4-nitrophenyl 7-morpholinylphosphonochloridate is reported.Its application to the preparation of 5'-phosphorylated ribonucleosides (e.g. pA, ppA and pppA) as well as RNA fragments (e.g. pUpU and ppUpU) is demonstrated.Further, special attention is paid to the mild removal of the 4-nitrophenyl group from fully protected phosphotriester intermediates.