2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one is a synthetic chemical compound characterized by the presence of a pyrazole ring and a pyrimidine ring. It is recognized for its potent inhibitory activity against dihydroorotate dehydrogenase (DHODH), a key enzyme in the biosynthesis of pyrimidine. The unique chemical structure and properties of 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one render it a significant entity for pharmaceutical research and development, with potential applications in various therapeutic areas.
79871-77-5
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Basic information
- Product Name: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one
- Synonyms: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one
- CAS NO:79871-77-5
- Molecular Formula:
- Molecular Weight: 233.273
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one(CAS DataBase Reference)
- NIST Chemistry Reference: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one(79871-77-5)
- EPA Substance Registry System: 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one(79871-77-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 79871-77-5(Hazardous Substances Data)
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79871-77-5 Usage
Uses
Used in Pharmaceutical Industry:2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one is utilized as a DHODH inhibitor for its potential role in treating a range of conditions, including cancer, autoimmune diseases, and inflammatory disorders. 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one's ability to inhibit DHODH suggests that it could disrupt the biosynthesis of pyrimidine, thereby affecting the proliferation of cells involved in these diseases.
Used in Cancer Treatment:
In the field of oncology, 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one is considered as a therapeutic agent for its potential to impede the growth and spread of cancer cells. By targeting DHODH, it may help in limiting the availability of pyrimidine nucleotides essential for DNA replication and RNA synthesis, thus inhibiting tumor cell proliferation.
Used in Autoimmune Disease Management:
2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one is explored as a potential treatment for autoimmune diseases, where it may help in modulating the immune response. The inhibition of DHODH could lead to a reduction in the activity of immune cells that contribute to the inflammation and tissue damage characteristic of autoimmune conditions.
Used in Inflammatory Condition Therapy:
2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one is also being investigated for its potential application in the treatment of inflammatory conditions. The inhibition of DHODH by 2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one may reduce the production of pro-inflammatory mediators, thereby alleviating inflammation and associated symptoms.
Check Digit Verification of cas no
The CAS Registry Mumber 79871-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,8,7 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.Calculate Digit Verification of CAS Registry Number 79871-77:
(7*7)+(6*9)+(5*8)+(4*7)+(3*1)+(2*7)+(1*7)=195
195 % 10 = 5
So 79871-77-5 is a valid CAS Registry Number.
79871-77-5Upstream product
79871-77-5Downstream Products
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2-(5-amino-3-methyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one
