79876-23-6Relevant academic research and scientific papers
UREAS IN ORGANIC SYNTHESIS. V. REACTIONS OF AROMATIC KETONES AND 1,2-DIKETONES WITH UREAS IN FORMIC ACID
Bakibaev, A.A.,Yagovkin, A.Yu.,Filimonov, V.D.
, p. 1326 - 1331 (2007/10/02)
Urea in formic acid is a general and practical reagent for the reductive aminoformylation of benzophenones and fluoren-9-one in the synthesis of N-diarylmethylformamides, which exhibit antispasmodic activity.With benzophenone in formic acid 1,3-dimethylurea gives a high yield of N-methyl-N-benzhydrylformamide.Urea reacts selectively with benzil and benzoin, forming both the bicyclic bisurea and monocyclic nitrogen-containing heterocycles, depending on the temperature.It was proposed for the first time to use arylmethylenebisureas as reagents in reaction with benzil for the production of 1,5-diphenyl-2,4,6,8-tetraazabicyclooctane-3,7-dione or 2,4,5-triphenylimidazole.
A Gradative Deprotection Strategy for the Solid-Phase Synthesis of Peptide Amides Using p-(Acyloxy)benzhydrylamine Resin and the SN2 Deprotection Method
Tam, James P.
, p. 5291 - 5298 (2007/10/02)
An efficient deprotection strategy for the preparation of peptide amides by solid-phase peptide synthesis is described.The new method, gradative deprotection approach, utilized a multidetachable benzhydrylamine resin, p-(acyloxy)benzhydrylamine resin, and
DESIGN AND SYNTHESIS OF A MULTI-DETACHABLE BENZHYDRYLAMINE-RESIN FOR SOLID PHASE PEPTIDE SYNTHESIS
Tam, James P.,DiMarchi, Richard D.,Merrifield, R. B.
, p. 2851 - 2854 (2007/10/02)
Peptides with C-terminal α-carboxamides were synthesized from a multi-detachable benzhydrylamine-resin containing a Boc-(4-acetoxy)benzhydrylamine handle of unambiguous origin.The peptides bound to the new resin are stable to trifluoroacetic acid, but are cleavable by hydrogen fluoride, base and nucleophiles to give unprotected or protected peptide fragments.
