79879-28-0Relevant academic research and scientific papers
SYNTHESIS OF DERIVATIVES OF 1-AMINOETHYLPHOSPHONIC AND 1-AMINOETHYLPHOSPHINIC ACIDS AS SUBSTRATES FOR PENICILLINACYLASES
Solodenko, V. A.,Kasheva, T. N.,Mironenko, D. A.,Kozlova, E. V.,Shvyadas, V. K.,Kukhar, V. P.
, p. 1209 - 1215 (2007/10/02)
Racemic and optically active N-phenylacetyl derivatives of 1-aminoethylphosphonic acid, 1-aminoethylphosphinic acid, and their mono- and diesters have been synthesized to study the substrate specificity of penicillinacylases.
Preparation of optically active 1-aminoalkylphosphonic acids by stereoselective enzymatic hydrolysis of racemic N-acylated 1-aminoalkylphosphonic acids
Solodenko,Kasheva,Kukhar,Kozlova,Mironenko,Svedas,Belozersky
, p. 3989 - 3998 (2007/10/02)
N-Phenylacetylated derivatives of 1-aminoalkylphosphonic acids were synthesized and high enantioselectivity of their hydrolysis by penicillin acylase (EC 3.5.1.11) was demonstrated. Stereoselective enzymatic hydrolysis of racemic 1-(N-phenylacetylamino) alkylphosphonic acids was used for preparation of enantiomeric 1-aminoalkylphosphonic acids. The kinetic regularities of penicillin acylase catalyzed hydrolysis were established and the biocatalytic process was optimized to increase the optical purity and the yield of the optically active product.
