79886-55-8

Basic information

• Product Name: N-Succinimidyl 4-(4-maleimidophenyl)butyrate
• Synonyms: N-SUCCINIMIDYL 4-(P-MALEIMIDOPHENYL)BUTYRATE;N-SUCCINIMIDYL 4-(4-MALEIMIDOPHENYL)BUTYRATE;SMPB;SUCCINIMIDYL 4-[P-MALEIMIDOPHENYL]BUTYRATE;SUCCINIMIDYL 4-(4-MALEIMIDOPHENYL)BUTYRATE;4-(P-MALEIMIDOPHENYL)BUTYRIC ACID N-HYDROXYSUCCINIMIDE ESTER;4-(P-MALEIMIDOPHENYL)-BUTYRIC ACID N-HYDROXYSUCCINIMIDESTER;4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester
• CAS NO: 79886-55-8
• Molecular Formula: C18H16N2O6
• Molecular Weight: 356.33
• Product Categories: Maleimide Derivatives;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;Heterobifunctional Crosslinker;heteroXlink
• Mol File: 79886-55-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 130-131°C
• Boiling Point: 551.1 °C at 760 mmHg
• Flash Point: 287.1 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 3.41E-12mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• Solubility: Acetontrile (Slightly), DMSO (Slightly)
• PKA: -0.52±0.20(Predicted)
• CAS DataBase Reference: N-Succinimidyl 4-(4-maleimidophenyl)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: N-Succinimidyl 4-(4-maleimidophenyl)butyrate(79886-55-8)
• EPA Substance Registry System: N-Succinimidyl 4-(4-maleimidophenyl)butyrate(79886-55-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 79886-55-8(Hazardous Substances Data)

Usage

Description

N-Succinimidyl 4-(4-maleimidophenyl)butyrate is a heterobifunctional protein crosslinking reagent that contains both sulfhydryl and amino reactive groups. It is characterized by a spacer arm of 11.6 angstroms, which allows for the efficient and specific conjugation of proteins.

Uses

Used in Bioconjugation Applications:
N-Succinimidyl 4-(4-maleimidophenyl)butyrate is used as a crosslinking agent for the covalent attachment of proteins, particularly in the fields of biochemistry, molecular biology, and biotechnology. Its sulfhydryl and amino reactive groups enable the selective and specific conjugation of proteins, leading to the formation of stable and functional bioconjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, N-Succinimidyl 4-(4-maleimidophenyl)butyrate is used as a crosslinking agent for the development of drug delivery systems. Its ability to covalently attach proteins to drug carriers, such as nanoparticles or liposomes, allows for the targeted delivery of therapeutic agents to specific cells or tissues, improving the efficacy and reducing the side effects of the treatment.
Used in Biosensor Development:
N-Succinimidyl 4-(4-maleimidophenyl)butyrate is also employed in the development of biosensors, where it is used to immobilize proteins or enzymes onto sensor surfaces. The stable and specific attachment of proteins ensures the efficient and sensitive detection of target molecules, making it a valuable tool in diagnostics and environmental monitoring.
Used in Research and Development:
In academic and industrial research settings, N-Succinimidyl 4-(4-maleimidophenyl)butyrate is used as a versatile crosslinking agent for various applications, including the study of protein-protein interactions, the development of novel biomaterials, and the investigation of enzyme mechanisms. Its unique properties make it a valuable tool for advancing scientific knowledge and developing innovative solutions.

InChI:InChI=1/C18H16N2O6/c21-14-8-9-15(22)19(14)13-6-4-12(5-7-13)2-1-3-18(25)26-20-16(23)10-11-17(20)24/h4-9H,1-3,10-11H2