79902-91-3Relevant academic research and scientific papers
Studies on epimeric D-xylo-and D-lyxo -tetritol-1-yl-2-phenyl-2 H-1,2,3- triazoles. Synthesis and anomeric configuration of 4-(α- and β-D- threofuranosyl)- 2-phenyl-2H-1,2,3- triazole C-nucleoside analogs
Sallam, Mohammed A. E.,Louis, Farida F.,Cassady, John M.
, p. 941 - 954 (2000)
Treatment of 4-(D-xylo-tetritol-1-yl)-2-phenyl-2H-1,2,3-triazole (1) with one mole equivalent of tosyl chloride in pyridine solution, afforded the C-nucleoside analog; 4-(β-D-threofuranosyl)-2-phenyl-2H-1,2,3-triazole (2) in 55% yield, as well as the bypr
Studies on epimeric-D-arabino- and -D-ribo-tetritol-1-yl-2-phenyl-2 h- 1,2,3-triazoles. Synthesis and anomeric configuration of 4-(α- and β-D- erythrofuranosyl)-2-phenyl-2 h-1,2,3-triazole C-nucleoside analogs
Sallam, Mohammed A. E.,Louis, Farida F.,Cassady, John M.
, p. 769 - 783 (2007/10/03)
Treatment of 4-(D-arabino-tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole (1) with one mole equivalent of tosyl chloride in pyridine solution, afforded the C-nucleoside analogs, 4-(α-D-erythrofuranosyl)-2-phenyl-2 H- 1,2,3-triazole (2) in 25% yield, as well as the byproduct 4-(4-chloro-4-deoxy-D-arabino- tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole(3). Treatment of the epimeric 4- (D-ribo-tetritol-l-yl)-2-phenyl-2 H-1,2,3-triazole(8) with tosyl chloride in pyridine solution afforded the anomeric C-nucleoside analogs, 4-(β-D- erythrofuranosyl)-2-phenyl-2 H-1,2,3-triazole (9) in 23% yield. Similar treatment of 8 with trifluoromethanesulfonyl chloride in pyridine solution afforded 9. The structure and anomeric configuration of these compounds were determined by acylation, NMR, NOE, circular dichroism spectroscopy and mass spectrometry.
