79907-49-6Relevant academic research and scientific papers
THE ACID-CATALYSED RING CONTRACTION OF TETRAHYDRO-1-BENZOXEPIN-3-OL TO 2-HYDROXYMETHYLCHROMAN DERIVATIVES.
Dean, Francis M.,Jones, Michael A.
, p. 2495 - 2496 (1983)
Derivatives of 2,3,4,5-tetrahydro-3-methyl-1-benzoxepin-3-ol are readily isomerised by acids into the corresponding derivatives of 2-hydroxymethyl-2-methyl chroman.
Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives
Xu, Qian,Zhang, Luyun,Zhan, Dazhao,Xia, Guangqing,Zhu, Junyi,Zang, Hao
, p. 645 - 650 (2020)
To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structu
Nitrone derivatives of trolox as neuroprotective agents
Balogh, Gyoergy T.,Vukics, Krisztina,Koenczoel, Arpad,Kis-Varga, Agnes,Gere, Aniko,Fischer, Janos
, p. 3012 - 3015 (2005)
Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.
Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids
Koufaki, Maria,Kiziridi, Christina,Alexi, Xanthippi,Alexis, Michael N.
, p. 6432 - 6441 (2009)
Novel 1,2-dithiolane/chroman hybrids bearing heterocyclic rings such as 1,2,4- and 1,3,4-oxadiazole, 1,2,3-triazole and tetrazole were designed and synthesized. The neuroprotective activity of the new analogues was tested against oxidative stress-induced cell death of glutamate-challenged HT22 hippocampal neurons. Our results show that bioisosteric replacement of amide group in 2-position of the chroman moiety, by 1,3,4-oxadiazole did not affect activity. However, analogue 5 bearing the 1,2,4-oxadiazole moiety showed improved neuroprotective activity. The presence of nitrogen heterocycles strongly influences the neuroprotective activity of 5-substituted chroman derivatives, depending on the nature of heterocycle. Replacement of the amide group of the first generation analogues by 1,2,4-oxadiazole or 1,2,3-triazole resulted in significant improvement of the activity against glutamate induced oxidative stress.
Trolox alcohol ester derivative, and preparation method and application thereof
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Paragraph 0065-0068, (2020/07/02)
The invention provides a Trolox alcohol ester derivative, and a preparation method and an application thereof, and belongs to the technical field of medicines. A carboxyl groups in Trolox is reduced into hydroxyl, then the hydroxyl group is modified, and
SYNTHESIS OF TOCOTRIENOLS FROM O-CRESOL DERIVATIVES
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Page/Page column 41, (2019/04/11)
The present invention provides an environmentally benign, facile process for preparation of Tocotrienols from commercially available derivatives of o-Cresol.
DEUTERATED EPI-743
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, (2017/06/12)
This invention relates to novel α-tocotrienol quinones of Formula I: (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treat
Synthesis of ionic biologically active conjugates from trolox and α-tocopherol succinates
Yushkova, Yu. V.,Morozov,Chernyak,Grigor’ev
, p. 1015 - 1019 (2018/03/21)
Six ionic conjugates with nitroxyl radical amino-TEMPO and diethanolamine as the amines were synthesized from trolox and α-tocopherol succinates. The water solubility of the synthesized ammonium salts was determined. It was shown that formation of the trolox succinate salts increased the water solubility whereas this phenomenon was not observed for α-tocopherol succinates.
Design and synthesis of biotinylated troglitazone as an active affinity probe
Li, Xin,Li, Xiaoqi,Tang, Hong,Nan, Fajun
experimental part, p. 2240 - 2244 (2011/10/12)
A biotin-tagged analogue of troglitazone was designed, synthesized and applied to affinity chromatography to pulldown EGFR from 293T cell lysates overexpressing EGFR, a membrane protein assumed to be troglitazone's direct binding target by previous work.
ANDROGEN RECEPTOT-ABLATIVE AGENTS
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Page/Page column 38, (2009/10/18)
Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating
