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Relevant academic research and scientific papers

Annulus fibrosus detection in intervertebral discs using molecular imaging agents

The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of

Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use

Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the ability to be excited by 1064 nanometer femtosecond pulses. Methods of preparing the amino( oligo )thiophene dyes are also described.

AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE

Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the ability to be excited by 1064 nanometer femtosecond pulses. Methods of preparing the amino(oligo)thiophene dyes are also described.

Amino(oligo)thiophene-based environmentally sensitive biomembrane chromophores

(Graph Presented) There is a growing need for cellular imaging with fluorescent probes that emit at longer wavelengths to minimize the effects of absorption, autofluorescence, and scattering from biological tissue. In this paper a series of new environmentally sensitive hemicyanine dyes featuring amino(oligo)thiophene donors have been synthesized via aldol condensation between a 4-methylpyridinium salt and various amino(oligo)thiophene carboxaldehydes, which were, in turn, obtained from amination of bromo(oligo)thiophene carboxaldehyde. Side chains on these fluorophores impart a strong affinity for biological membranes. Compared with benzene analogues, these thiophene fluorophores show significant red shift in the absorption and emission spectra, offering compact red and near-infrared emitting fluorophores. More importantly, both the fluorescence quantum yields and the emission peaks are very sensitive to various environmental factors such as solvent polarity or viscosity, membrane potential, and membrane composition. These chromophores also exhibit strong nonlinear optical properties, including two-photon fluorescence and second harmonic generation, which are themselves environmentally sensitive. The combination of long wavelength fluorescence and nonlinear optical properties make these chromophores very suitable for applications that require sensing or imaging deep inside tissues.

Long Chain Heterocyclic Dyes. Part Two. Surface Active Dyes

A series of heterocyclic cyanine dyes were prepared.Unsymmetrical dyes showed self-micellizing properties due to the presence of two positive charges and of a long alkyl chain.Symmetrical dyes, containing three positive charges and not containing the hydrophobic chain, did not give rise to micelles.The physical properties of the dyes and their spectra were briefly discussed.Cationic (HTAB) and anionic (SDS) surfactants gave strong interactions with surface active dyes, leading to deaggregation and solvation phenomena.

Synthesis, Surface Activity and Micelle Formation of Novel Cyanine Dyes

The synthesis, surface activity and micelle formation of three novel cyanine dyes with amphiphilic character is described.It is illustrated by combined surface tension and absorption measurements that in one case self-assembly is highly cooperative leadin