79923-51-6

Basic information

• Product Name: 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol hydrochloride
• CAS NO: 79923-51-6
• Molecular Formula: C₁₀H₁₄ClNO₂
• Molecular Weight: 215.68
• Mol File: 79923-51-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol hydrochloride(79923-51-6)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol hydrochloride(79923-51-6)

Safety Data

• Hazardous Substances Data: 79923-51-6(Hazardous Substances Data)

Usage

Type of compound

chemical compound

Natural occurrence

found in various plants, particularly in the opium poppy

Chemical structure

includes a tetrahydroisoquinoline core and a hydroxyl group

Pharmacological properties

analgesic and psychoactive effects

Potential use

treatment of various medical conditions

Potential use

precursor in the synthesis of various pharmaceuticals

Research focus

impact on dopamine receptors and potential role in addiction and substance abuse

Upstream product

• 62-31-7 dopamine hydrochloride 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Fluorometric determination of 1,2,3,4-Tetrahydro-6,7- dihydroxyisoquinoline in biological materials by HPLC

In the belief that endogenous 1,2,3,4-tetrahydro-6,7- dihydroxyisoquinoline (DA-Fp) could be a potential marker involved in the etiology of various diseases such as Parkinsonism, we attempted to develop a fluorescence method for DA-Fp. It was synthesized by condensation of dopamine with formaldehyde according to an established method. Periodate was identified by screening from various oxidation reagents as a fluorescence reagent to DA-Fp. Optimal reaction conditions were obtained with 0.25 mM NaIO4 in 0.1 M phosphate buffer (pH 8.0) at 37 °C for 15 min. The fluorescence spectrum of the derivative showed that we had found new reaction specific for DA-Fp. This reaction was coupled on-line to high performance liquid chromatography (HPLC, which enabled us to achieve a highly sensitive method for determining DA-Fp. A working curve was linear from 2 to 800 pmol of DA-Fp per injection. To determine DA-Fp in biological materials, the pretreatment before HPLC was optimized by hydrolysis of its conjugate and suppression of the artifact with l-phenylephrine. Urinary excretion of DA-Fp in men was measured by this new present method. The urinary excretion of endogenous DA-Fp increased in a rabbit given L-DOPA. The DA-Fp concentration was determined in rat brain. The significance of DA-Fp in these biological materials is discussed and evaluated. We conclude that the present method will be useful for studying tetrahydroisoquinolines involved in many diseases.

1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof

A 1,2,3,4-tetrahydroisoquinoline having the formula: SPC1 Which has relaxing activity on smooth muscles.