799267-99-5

Upstream product

• 501-53-1 benzyl chloroformate 
• 554-62-1 D-ribo-phytosphingosine 
• 634587-44-3 (2S,3S,4R)-2-benzyloxycarbonylamino-3,4-di-O-isopropy-lidene-1,3,4-octadecanetriol 
• 634587-42-1 (2S,3R,4R)-1-O-tert-butyldimethysilyl-2-benzyloxycarbonylamino-3,4-di-O-isopropylidene-1,3,4-octadecanetriol 

Downstream Products

• 799267-95-1 [(S)-1-((4S,5R)-2,2-Dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-allyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases

The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.

Efficient synthesis of α-C-galactosyl ceramide immunostimulants: Use of ethylene-promoted olefin cross-metathesis

(Chemical Equation Presented) Olefin cross-metathesis has been used to prepare α-C-galactosylceramide derivatives. The metathesis process merged vinyl and propenyl glycosides with vinyl derivatives of phytosphingosine. The use of ethylene enhanced the yie