79930-48-6

Upstream product

• 5419-00-1 5-ethyl-1-phenyl-pyrimidine-2,4,6-trione 
• 64-10-8 phenyl carbamate 
• 16951-16-9 5-ethyl-5-bromo-1-phenyl-barbituric acid 

Downstream Products

• 221679-70-5 5-amino-5-ethyl-1-phenylbarbituric acid 

Relevant academic research and scientific papers

A new one-pot synthesis of 5,5-disubstituted hydantoins from diethyl acetamidomalonates and ureas

A new one-pot synthesis of 5,5-disubstituted hydantoins 3 is reported. Diethyl 2-acetamido-2-alkylmalonates were found to react with substituted ureas in the presence of sodium ethoxide to produce the 5-alkyl-5- carbamoylhydantoins 3 a-e. The reaction involves a ring contraction of intermediate 5-aminobarbituric acids to the final hydantoin derivatives. The 5-aminobarbituric acids 2 d-f were prepared from azido derivatives 6 d-f. On treatment with sodium ethoxide, 2 d-f underwent the rearrangement to afford the hydantoins 3 d-f.