79946-44-4Relevant academic research and scientific papers
Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Reactions of 2-Cyanomethyl-3,1-benzoxazin-4(H)-one with Nucleophilic Reagents, Acid Anhydrides and Acid Imides
Mohamed, M. M.,El-Hashash, M. A.,Esswy, A.,Shaban, M. E.
, p. 718 - 719 (2007/10/02)
Reaction of 2-cyanomethyl-3,1-benzoxazin-4(H)-one (I) with hydrazines, aniline and sulphamidic compounds gives 4(3H)-quinazolinones (II) or N-cyanoacetylanthranilic acid arylhydrazides (III), o-(cyanoacetamido)benzanilide (IV) and anilide derivatives (IX,X), respectively.Condensation of I with active methylene compounds, benzene (under Friedel-Crafts conditions), acid anhydrides and acid imides has also been investigated.
