79962-56-4

Upstream product

• 62-53-3 aniline 
• 158362-15-3 spirooxathialane>-2,5'-dione 
• 91-56-5 indole-2,3-dione 
• 68-11-1 mercaptoacetic acid 
• 101671-27-6 3-(phenylimino)-1,3-dihydro-2H-indol-2-one 
• 33828-98-7 3-phenylimino-2-indolinone 

Downstream Products

• 879561-37-2 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dion-1-ylacetatyl hydrazine 
• 1040725-54-9 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione-1-yl acetonitrile 
• 879561-35-0 ethyl (3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dion-1-yl)acetate 

Relevant academic research and scientific papers

The influence of the polymerization approach on the catalytic performance of novel porous poly (ionic liquid)s for green synthesis of pharmaceutical spiro-4-thiazolidinones

Although poly (ionic liquids) (PILs) have attracted great research interest owing to their various applications, the performance of nanoporous PILs has been rarely developed in the catalysis field. To this end, a micro-mesoporous PIL with acid-base bifunc

Anti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis

Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3?OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and ev

Indole-2-ketone-3-spirobuprofezin or thiazolone compound and application thereof

The invention discloses an indole-2-ketone-3-spirobuprofezin or thiazolone compound shown as a formula I or pharmaceutically acceptable salt thereof or a stereoisomer thereof and application thereof to preparation of a medicine for preventing and treating

Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water

An energy-efficient eco-friendly methodology for the synthesis of a series of pharmacologically important spiro[indoline-3,2′-thiazolidinones] has been developed by the reaction of primary amines with various isatin derivatives and thioglycolic acid in the presence of p-dodecylbenzenesulfonic acid (DBSA) as an efficient Br?nsted acid surfactant combined catalyst in aqueous medium at 25 °C. This synthetic protocol demonstrates several advantages such as operational simplicity, energy-efficiency, good to excellent isolated yields, and the use of a preferred green solvent system for the preparation of desired products.

"On water" synthesis of spiro-indoles via Schiff bases

A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic am

Microwave-Assisted, Solvent-Free Synthesis of 3′-(Aryl/Heteroaryl)-1- morpholinomethyl/piperidinomethylspiro[3H- Indole-3,2′-thiazolidine]-2, 4′(1H)-diones via 3-Isatinimines

The solvent-free, microwave (MW)-assisted synthesis of a new series of 3′-(aryl/heteroaryl)-1-mor-pholinomethyl/piperidinomethylspiro[3H-indole- 3,2′-thiazolidine]-2,4′(1H)-diones has been achieved in an open vessel. Isatins 1 undergo an easy condensation

Synthesis, partition coefficients and antibacterial activity of 3′-phenyl (substituted)-6′-aryl-2′(1H)-cis-3′,3′ a -dihydrospiro[3-H-indole-3,5′-pyrazolo (3′,4′-d)-thiazolo-2- (1H)-ones]

Condensation of isatin with primary aryl amines gave a series of Schiff bases (1) which on reaction with thioglycolic acid in 1,4-dioxane afforded the formation of the corresponding 4- thiazolidinones (2). Compound 2 on condensation with substituted benza

Synthesis, partition coefficient and antibacterial activity of 3′-aryl-6′-phenyl(substituted)-cis-5′a,6′- dihydrospiro[3H-indole-3,4′-thiozolo(5′,1′-c)-isoxazolo-2-(1H) -ones]

Condensation of isatin with primary aryl amines gave a series of Schiff bases (1) which on reaction with thioglycolic acid in 1,4-dloxane afforded the corresponding thiazolidones (2). Compound 2 on condensation with substituted benzaldehydes in anhydrous

Microwave-induced one-pot synthesis of some new spiro [indoline -3,2'- thiazolidine]-2,4'(1H)-diones and bis [spiro [indoline-3,2'-thiazolidinei- 2,4'(1H)-diones]

The title compounds have been obtained thermally and under microwave irradiation by condensation of isatin, aromatic amines and mercaptoacetic acid in good to excellent yields without isolating the imine intermediates.

SYNTHESIS OF SOME NEW SPIROHETEROCYCLES RELATED TO SPIROOXATHIALANE>-2,5'-DIONE

The reaction of indole-2,3-dione (1a) and/or 1-methylindole-2,3-dione (1b) with mercaptoacetic acid in the presence of 4-toluenesulfonic acid as a catalyst afforded spirooxathialane>-2,5'-diones (2a, b).Compounds 2a and/or 2 b were reacted with the appropriate aliphatic and/or aromatic primary amines to give compounds 3a-j.The reaction of 2a, b with hydrazine hydrate, phenylhydrazine and p-nitrophenylhydrazine yielded spiroderivatives 4a-c.Friedel-Crafts reactions of 2a and 2b with arenes in the presence of aluminium chloride catalyst afforded spiroindoline isothiochroman derivatives 5a-h.Key words: Spiroindoline derivatives; spiroheterocycles; NMR.