79965-42-7Relevant academic research and scientific papers
Synthesis of α,α-disubstituted acetic acids using low-valent titanium
Garcia, Mariano,Campo, Carmen del,Llama, Emilio F.,Sinisterra, Jose V.
, p. 1771 - 1774 (2007/10/02)
Digalogenocarbenes generated using low-valent titanium (LVT) undergo a one-pot cycloaddition to diaryl, aryl alkyl or dialkyl ketones to give α,α-disubstituted acetic acids such as (R,S)-2-arylpropanoic acids.TiI4 proved most effective in this reaction for which the product yield was optimized by use of an excess of reducing agent.
