79974-41-7

Usage

Chemical structure

A complex structure consisting of a pentofuranosyl group, a 1H-pyrazol-5-amine core, and a 1H-1,2,4-triazol-5-yl group.

Pentofuranosyl group

A sugar-based moiety derived from pentose, which is a five-carbon sugar.

1H-pyrazol-5-amine core

The central part of the compound, which is a pyrazole ring fused with an amine group (-NH2).

1H-1,2,4-triazol-5-yl group

A substituent containing a 1,2,4-triazole ring, which is a five-membered heterocyclic ring with three nitrogen atoms and two carbon atoms.

Potential pharmacological properties

Due to its unique structure, 1-pentofuranosyl-4-(1H-1,2,4-triazol-5-yl)-1H-pyrazol-5-amine may have possible applications in drug development or research.

Further studies needed

More research is required to fully understand the potential uses and effects of 1-pentofuranosyl-4-(1H-1,2,4-triazol-5-yl)-1H-pyrazol-5-amine.

Upstream product

• 79974-37-1 7-(β-D-ribofuranosyl)pyrazolo<4,3-e>-1,2,4-triazolo<1,5-c>pyrimidine 
• 79974-36-0 7-(2,3-O-ethoxymethylene-β-D-ribofuranosyl)pyrazolo<4,3-e>-1,2,4-triazolo<1,5-c>pyrimidine 
• 79974-35-9 5-amino-4-imino-1-(β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine hydrochloride 
• 3258-05-7 4-amino-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine 

Downstream Products

• 79974-42-8 7-(β-D-ribofuranosyl)pyrazolo<4,3-e>-1,2,4-triazolo<2,3-c>-1,2,3-triazine 

Relevant academic research and scientific papers

Synthesis of Certain Fluorescent Tricyclic Nucleosides Derived from PyrazoloPyrimidine Nucleosides

The synthesis of certain tricyclic nucleosides with a dihydroimidazole, imidazole, triazole, or tetrazole ring fused to the pyrazolopyrimidine ring system in an angular position (C-4 and N-5) has been accomplished.The 4-aziridinyl derivative (2) was prepared by a nucleophilic displacement of the chlorine atom of 4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolopyrimidine (1) with ethylenimine.The nucleoside (2) was then treated with sodium iodide to furnish 7-(β-D-ribofuranosyl)-2,3-dihydroimidazopyrazolopyrimidine (3).The reaction of (1) with lithium azide gave 7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolotetrazolopyrimidine (5) and cyclization of 4-amino-1-(β-D-ribofuranosyl)pyrazolopyrimidine with chloroacetaldehyde provided the tricyclic nucleoside 7-(β-D-ribofuranosyl)imidazopyrazolopyrimidine (7). 2,4-Dinitrophenoxamine was treated with 4-amino-1-(β-D-ribofuranosyl)pyrazolopyrimidine (6) to give an intermediate (8) which on cyclization with diethoxymethyl acetate gave 7-(2,3-O-methoxymethylene-β-D-ribofuranosyl)pyrazolo-1,2,4-triazolopyrimidine (9).Acid-catalysed deblocking of (9) provided the desired tricyclic nucleoside (10).The reaction of trimethyl orthoformate with 4-hydrazino-1-(β-D-ribofuranosyl)pyrazolopyrimidine under different experimental conditions resulted in the formation of a mixture of diastereoisomers due to the 2',3'-O-methoxymethylene group.Treatment of (10) with alkali gave a ring-opened intermediate which on treatment with sodium nitrite and acetic acid cyclized to give an aza-derivative (16) of (10).