79974-72-4

Basic information

• Product Name: 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin
• Synonyms: 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin
• CAS NO: 79974-72-4
• Molecular Weight: 632.829
• Mol File: 79974-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin(79974-72-4)
• EPA Substance Registry System: 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin(79974-72-4)

Safety Data

• Hazardous Substances Data: 79974-72-4(Hazardous Substances Data)

Upstream product

• 58-96-8 uridine 
• 5627-05-4 5,6-dihydrouridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 79974-71-3 5,6-Dihydro-5'-O-(4-methoxytrityl)uridin 

Relevant articles and documents

Nucleosides, XXXVII. - Synthesis and Properties of 2'-O- and 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4-methoxytrityl)- and 2',3'-Bis(O-tert-butyldimethylsilyl)ribonucleosides - Starting Materials for Oligoribonucleotide Syntheses

The synthesis of aminoacylated 5'-O-(4-methoxytrityl)ribonucleosides of adenosine (1), guanosine (9), cytidine (31), uridine (17), and 5,6-dihydrouridine (23) have been optimized and these compounds (4, 12, 33, 18 and 24) silylated by tert-butyldimethylsilyl chloride.The corresponding 2'- and 3'-mono-O- as well as 2',3'-bis-O-(tert-butyldimethylsilyl) derivatives have been isolated by combination of chromatographical methods and fractional crystallization procedures in preparative scale.The characterization of the newly synthesized compounds was achieved by UV and 13C-NMR spectra.