79975-06-7

Usage

Discovery year

1967
This sweetener was discovered in the year 1967.

Sweetness comparison

200 times sweeter than sucrose
Acesulfame K is approximately 200 times sweeter than table sugar (sucrose).

Usage

Combined with other sweeteners
It is often mixed with other sweeteners to enhance their sweetness.

Industry application

Food and beverage industry
Acesulfame K is commonly used in the food and beverage industry as a low-calorie sugar substitute.

Typical products

Soft drinks, chewing gum, dairy products
This sweetener is used in products such as soft drinks, chewing gum, and dairy products.

Chemical structure

Nitrogen, carbon, oxygen, and hydrogen atoms
The chemical structure of Acesulfame K contains these four types of atoms.

Key functional groups

Benzene ring and ketone group
The sweet taste of Acesulfame K comes from the presence of a benzene ring and a ketone group in its molecular structure.

Safety controversies

Some controversies exist

Regulatory approval

Approved by various countries' authorities
Despite the controversies, Acesulfame K is approved for consumption by regulatory authorities in various countries around the world.

Upstream product

• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 142-25-6 N,N',N'-trimethylenediamine 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 33451-85-3 N′-(2-aminoethyl)-N′,N,N-trimethylethan-1,2-diamine 

Relevant academic research and scientific papers

Neutral and Anionic Monomeric Zirconium Imides Prepared via Selective C=N Bond Cleavage of a Multidentate and Sterically Demanding β-Diketiminato Ligand

A sterically encumbering multidentate β-diketiminato ligand, tBuL2 (tBuL2=[ArNC(tBu)CHC(tBu)NCH2CH2N(Me)CH2CH2NMe2]?, Ar=2,6-iPr2C6H3), is reported in this study along with its coordination chemistry to zirconium(IV). Using the lithio salt of this ligand, Li(tBuL2) (4), the zirconium(IV) precursor (tBuL2)ZrCl3 (6) could be readily prepared in 85 % yield and structurally characterized. Reduction of 6 with 2 equiv of KC8 resulted in formation of the terminal and mononuclear zirconium imide-chloride [C(tBu)CHC(tBu)NCH2CH2N(Me)CH2CH2NMe2]Zr(=NAr)(Cl) (7) as the result of reductive C=N cleavage of the imino fragment in the multidentate ligand tBuL2 by an elusive ZrII species (tBuL2)ZrCl (A). The azabutadienyl ligand in 7 can be further reduced by 2 e? with KC8 to afford the anionic imide [K(THF)2]{[CH(tBu)CHC(tBu)NCH2CH2N(Me)CH2CH2N(Me)CH2]Zr=NAr} (8-2THF) in 42 % isolated yield. Complex 8-2THF results from the oxidative addition of an amine C?H bond followed by migration to the vinylic group of the formal [C(tBu)CHC(tBu)NCH2CH2N(Me)CH2CH2NMe2]? ligand in 7. All halides in 6 can be replaced with azides to afford (tBuL2)Zr(N3)3 (9) which was structurally characterized, and reduction with two equiv of KC8 also results in C=N bond cleavage of tBuL2 to form [C(tBu)CHC(tBu)NCH2CH2N(Me)CH2CH2NMe2]Zr(=NAr)(N3) (10), instead of the expected azide disproportionation to N3? and N2. Solid-state single crystal structural studies confirm the formation of mononuclear and terminal zirconium imido groups in 7, 8-Et2O, and 10 with Zr=NAr distances being 1.8776(10), 1.9505(15), and 1.881(3) ?, respectively.

Sequence-Specific Osmium Reagents for Polynucleotides. 2. A Method for Thymine-Cytosine Pairs

We have modified the dinucleoside monophosphate, deoxythymidylyldeoxycytidine (d-TpC), by replacement of the exocyclic amino group of cytosine with a series of ligands, H2N(CH2)nN(CH3)CH2CH2N(CH3)2, where n = 2, 4, and 6.The kinetics of the reactions of these modified dinucleoside monophosphates with osmium tetroxide were measured.The modified nucleotides react with osmium tetroxide 4200, 7900, and 1200 times faster than the unmodified species for n = 6, 4, and 2, respectively.The products of the reactions are macrocyclic oxoosmium (VI) esters for which 360-MHz proton NMR spectra are reported.