799801-45-9

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 93536-06-2 4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide 

Downstream Products

• 1009069-49-1 4-(8,8-dimethyl-4,6-dioxo-5-phenyl-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 
• 1009069-51-5 N-[3-cyano-7,7-dimethyl-5-oxo-4-phenyl-1-(4-sulfamoyl-phenyl)-1,4,5,6,7,8-hexahydro-quinolin-2-yl]acetamide 
• 1009069-53-7 4-[3-cyano-7,7-dimethyl-5-oxo-4-phenyl-2-(3-phenyl-ureido)-5,6,7,8-tetrahydro-4H-quinolin-1-yl]benzenesulfonamide 
• 1009069-55-9 4-(8,8-dimethyl-2,6-dioxo-5-phenyl-4-phenylamino-1,5,6,7,8,9-hexahydro-2H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 
• 1009069-60-6 4-(3-cyano-7,7-dimethyl-5-oxo-4-phenyl-2-(3-phenyl-thioureido)-5,6,7,8-tetrahydro-4H-quinolin-1-yl)benzenesulfonamide 
• 1009069-61-7 4-(4-imino-8,8-dimethyl-6-oxo-3,5-diphenyl-2-thioxo-1,3,4,5,6,7,8,9-octahydro-2H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 
• 1009069-52-6 4-(4-amino-8,8-dimethyl-6-oxo-5-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 
• 1009069-59-3 4-(4-amino-8,8-dimethyl-6-oxo-5-phenyl-2-thioxo-1,5,6,7,8,9-hexahydro-2H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 
• 1009069-56-0 4-(2-benzenesulfonylamino-3-cyano-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-quinolin-1-yl)benzenesulfonamide 
• 1009069-57-1 4-(3-cyano-7,7-dimethyl-5-oxo-4-phenyl-2-p-tolylsulfonylamino-5,6,7,8-tetrahydro-4H-quinolin-1-yl)benzenesulfonamide 
• 1009069-58-2 4-(4-amino-8,8-dimethyl-2,6-dioxo-5-phenyl-1,5,6,7,8,9-hexahydro-2H-pyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Utility of 4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide in the synthesis of novel quinolines as possible anticancer and radioprotective agents

The present work reports the possible utility of 4-(5,5-dimethyl-3-oxo- cyclohex-1-enylamino)benzenesulfonamide in the synthesis of some novel 4-(quinolin-1-yl) benzenesulfonamide derivatives (6a-o). Structures of the newly synthesized compounds were conf

Synthesis of some novel quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety as potential anticancer and radioprotective agents

Some novel 4-(quinolin-1-yl)-benzenesulfonamide and 4-(pyrimido[4,5-b] quinolin-10-yl)-benzenesulfonamide derivatives have been synthesized. All the newly synthesized target compounds were subjected to in vitro cytotoxic screening to be evaluated for their anticancer activity against Ehrlich ascites carcinoma cells. Among these new compounds, compounds 9a, 11, 12b, 18 and, in particular, 19 showed promising in vitro cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Moreover, compound 8 exhibited in vivo radioprotective activity against γ-irradiation in mice. ECV Editio Cantor Verlag.