799821-75-3

Basic information

• Product Name: 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-methyl-9-(3-phenylpropyl)-, ethyl ester
• CAS NO: 799821-75-3
• Molecular Formula: C24H24N2O2
• Molecular Weight: 372.467
• Mol File: 799821-75-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-methyl-9-(3-phenylpropyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-methyl-9-(3-phenylpropyl)-, ethyl ester(799821-75-3)
• EPA Substance Registry System: 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-methyl-9-(3-phenylpropyl)-, ethyl ester(799821-75-3)

Safety Data

• Hazardous Substances Data: 799821-75-3(Hazardous Substances Data)

Upstream product

• 5470-37-1 1-methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid 
• 637-59-2 1-Bromo-3-phenylpropane 
• 191279-39-7 ethyl 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate 
• 33821-71-5 ethyl 1-methyl-9H-pyrido[3,4-b]indole-3-carboxylateyl-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole-3-carboxylate 
• 39824-90-3 ethyl 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate 
• 73-22-3 L-Tryptophan 
• 191279-37-5 (3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid 

Downstream Products

• 1256282-52-6 9-(3-phenylpropyl)-1-methyl-β-carboline-3-carboxaldehyde 

Relevant articles and documents

Synthesis and preliminary evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors

A series of novel bivalent β-carbolines linked with an alkyl diamine spacer at the C-3 position were synthesized and evaluated as potent angiogenesis inhibitors. The results demonstrated that most bivalent β-carbolines displayed significant anti-proliferative effects against EA.HY926 human umbilical vein cell lines. Compound 8z was found to be the most potent anti-proliferative agent with an IC50 value of 1.10 μM against EA.HY926 cell lines. Preliminary investigations on the mechanisms of action revealed that compound 8z could dramatically inhibit EA.HY926 cell migration and tube formation in a dose-dependent manner. Moreover, compound 8z exhibited significant angiogenesis inhibitory effects in CAM assay, and the anti-angiogenic potency was comparable with that of the reference drug Endostar. These molecules might serve as candidates for further development into vascular-targeting antitumor drugs.

Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives

A series of novel 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives was synthesized from the starting material l-tryptophan. Cytotoxic activities of these compounds were investigated in vitro. The results showed that 1,3,9-trisubstituted β-carboline derivatives had higher cytotoxic activities in vitro than the corresponding 1,3-bisubstituted compounds. Among all the synthesized 1,3,9-trisubstituted β-carboline derivatives, the compounds with a methyl substituent at position-1 displayed more potent cytotoxic activities, furthermore compound 5e having an ethoxycarbonyl substituent at position-3 and a pentafluorobenzyl at position-9, respectively, was found to be the most potent compounds of this series with IC50 value of 4:uM against BGC-823 cell lines. These data suggested that (1) the cytotoxic potencies of β-carboline derivatives were enhanced by the introduction of appropriate substituents into position-1 and position-9 in β-carboline; (2) the β-carboline structure might be an important basis for the design and synthesis of new antitumor drugs; (3) the methyl substituent at position-1, the pentafluorobenzyl group at position-9 and the ethoxycarbonyl substituent at position-3 were the optimal combination for the improvement of cytotoxic activity of the β-carboline derivatives.