80003-54-9

Basic information

• Product Name: 1-Amino-2-ethenylcyclopropanecarboxylicacid
• Synonyms: 1-Amino-2-ethenylcyclopropanecarboxylicacid;Cyclopropanecarboxylic acid, 1-amino-2-ethenyl- (9CI);1-Amino-2-vinylcyclopropanecarboxylic acid;1-amino-2-ethenylcyclopropane-1-carboxylic acid
• CAS NO: 80003-54-9
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.14116
• Product Categories: AMINOACID
• Mol File: 80003-54-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 234.887 °C at 760 mmHg
• Flash Point: 95.856 °C
• Appearance: /
• Density: 1.377 g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 1-Amino-2-ethenylcyclopropanecarboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-2-ethenylcyclopropanecarboxylicacid(80003-54-9)
• EPA Substance Registry System: 1-Amino-2-ethenylcyclopropanecarboxylicacid(80003-54-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 80003-54-9(Hazardous Substances Data)

Usage

General Description

1-Amino-2-ethenylcyclopropanecarboxylic acid is a complex organic chemical compound with the molecular formula C7H9NO2. As its name suggests, it is an amino acid, which is one of the building blocks of proteins, with an additional ethenyl (vinyl) and a cyclopropane group attached to it. The structure of this compound includes a carboxylic acid group (-COOH) and an amino group (-NH2), which are characteristic features of all amino acids. Information about its specific uses, properties, and safety measures are not readily available and this compound might be used for specific purposes in chemical and pharmaceutical research.

InChI:InChI=1/C6H9NO2/c1-2-4-3-6(4,7)5(8)9/h2,4H,1,3,7H2,(H,8,9)

Upstream product

• 681260-04-8 (1R,2S)-1-amino-2-vinyl-cyclopropyl carboxylic acid methyl ester 
• 862273-27-6 (1R,2S)-1-amino-2-vinylcyclopropane carboxylic acid methyl ester tosylate salt 
• 159622-10-3 (1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid 
• 213316-32-6 rac-(1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester 

Downstream Products

• 159622-09-0 (1R,2S)-1-tert-butoxycarbonylamino-2-vinyl-cyclopropanecarboxylic acid methyl ester 
• 159622-10-3 (1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid 

Relevant articles and documents

METHOD FOR SYNTHESIZING OPTICALLY ACTIVE a-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL] ACETAMIDE COMPOUND AND AMINO ACID

Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid. The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

Preparation method for alpha-amino acid

The invention provides a preparation method for an alpha-amino acid and belongs to the pharmaceutical technical field. The preparation method comprises the following steps: in the presence of an alkali, performing a reaction of a metal complex in an organic solvent to obtain a complex; and then hydrolyzing the complex and/or reacting with a protecting agent to obtain the alpha-amino acid or derivatives thereof. The method provided by the invention can simply obtain the amino acid or derivatives thereof without splitting the product, so that the yield is high, the cost is low, and industrial production is facilitated.

METHOD FOR SYNTHESIZING OPTICALLY ACTIVE α-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL]ACETAMIDE COMPOUND AND AMINO ACID

Objects of the present invention are to provide an industrially applicable method for producing an optically active ±-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ±,±-disubstituted ±-amino acid, and to provide an intermediate useful for the above production methods of an optically active ±-amino acid and an optically active ±,±-disubstituted ±-amino acid. The present invention provides a production method of an optically active ±-amino acid or a salt thereof, the production method comprising introducing a substituent into the ± carbon in the ±-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure ±-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.