8001-27-2 Usage
Uses
Used in Pharmaceutical Industry:
Hirudin is used as an anticoagulant for the treatment of heparin-associated thrombocytopenia, myocardial infarcts, unstable angina, and cardiovascular events. It offers several advantages over heparin, such as not being inhibited by activated platelets and not increasing platelet activity.
Used in Research Applications:
Recombinant hirudin from yeast is used as an inhibitor in mannan-binding lectin serine protease 2 (MASP2) activation assays, providing a specific and potent tool for studying the activity of MASP2 in various biological processes.
Used in Platelet Adhesion Assays:
Hirudin is used as a pre-treatment for nanosheets in phosphate-buffered saline (PBS) to study platelet adhesion, providing a controlled environment to investigate the interactions between platelets and various surfaces.
Originator
Hoechst Merion Roussel (Germany)
Biochem/physiol Actions
The anticoagulant, hirudin, is the most potent natural inhibitor of both soluble and clot-bound thrombin. It forms a high-affinity 1:1 complex with thrombin, occluding both the proteolytic site and exosite I (fibrinogen and PAR recognition site). Hirudin blocks thrombus growth and platelet activation, and has been suggested as the clinically preferred anticoagulant (over heparin and citrate) for its specific mode of action and absence of side effects. It is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration.
Check Digit Verification of cas no
The CAS Registry Mumber 8001-27-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 8,0,0 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 8001-27:
(6*8)+(5*0)+(4*0)+(3*1)+(2*2)+(1*7)=62
62 % 10 = 2
So 8001-27-2 is a valid CAS Registry Number.