80012-47-1 Usage
General Description
1,13b-Dihydrodibenz(b,f)imidazo(1,5-d)(1,4)oxazepin-3-amine hydrochloride is a chemical compound with potential pharmacological and biological properties. It belongs to the class of imidazobenzodiazepine derivatives and is used in various research and medical applications. This chemical has been studied for its potential as a psychoactive drug, with its effects being similar to benzodiazepines. It has also shown potential as an anticonvulsant and anxiolytic agent. Additionally, it has been investigated for its potential in the treatment of mood disorders, anxiety, and insomnia. The hydrochloride salt form of this compound is often used for its increased stability and solubility in aqueous solutions. Overall, 1,13b-Dihydrodibenz(b,f)imidazo(1,5-d)(1,4)oxazepin-3-amine hydrochloride is a compound of interest in the field of pharmacology and has potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 80012-47-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,0,1 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 80012-47:
(7*8)+(6*0)+(5*0)+(4*1)+(3*2)+(2*4)+(1*7)=81
81 % 10 = 1
So 80012-47-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H13N3O.BrH/c16-15-17-9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)18(12)15;/h1-8,12H,9H2,(H2,16,17);1H
80012-47-1Relevant articles and documents
New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine
Walther,Daniel,Bechtel,Brandt
, p. 440 - 446 (2007/10/02)
A series of new tetracyclic guanides were synthesized by various methods. Specific binding of the described compounds to histamine-1 and histamine-2 receptors was determined. The compound 3-amino-9, 13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine (epinastine, WAL 801) combines high selectivity with high affinity for the H1 receptor and was selected from the compounds studied for further pharmacological and clinical investigations. Experimentally determined physicochemical parameters (pk(a)-value, partition coefficient) and the hydrogen-bonding ability of epinastine are indications that this compound will not easily cross the blood-brain barrier. This explains the absence of CNS side-effects of epinastine in pharmacological and clinical studies.
