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Uridine 2'-O-[(4-methoxyphenyl)methyl], also known as 4-Methoxyphenylmethyl-2'-O-uridine, is a chemical compound derived from the nucleoside uridine. It is characterized by the presence of a 4-methoxyphenylmethyl group attached to the 2'-O position of the uridine molecule. This modification enhances the stability and bioactivity of the compound, making it a valuable tool in various research applications, particularly in the fields of molecular biology and drug development. The compound is often used in the synthesis of modified nucleic acids, which can be employed for studying gene expression, RNA interference, and other biological processes. Its unique structure also allows for the investigation of molecular interactions and the development of potential therapeutic agents targeting specific genetic disorders.

80015-57-2

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80015-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80015-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,0,1 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 80015-57:
(7*8)+(6*0)+(5*0)+(4*1)+(3*5)+(2*5)+(1*7)=92
92 % 10 = 2
So 80015-57-2 is a valid CAS Registry Number.

80015-57-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]oxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:80015-57-2 SDS

80015-57-2Relevant academic research and scientific papers

An Improved Method for the Application of the 4-Methoxybenzyl Group to Protect the 2'-Hydroxyl Group in the Ribonucleotide Synthesis by TFA-acidolysis

Losse, G.,Pechstein, Birgit

, p. 46 - 54 (2007/10/02)

The cleavage of the 4-methoxybenzyl group from the 2'-OH-position of ribonucleosides by the hydrogenation with different Pd-catalysts as well as trifluoroacetic acid has been studied in detail.During hydrogenation, side reactions at the base residue of cytidine occurred which, however, could be extensively suppressed by PdCl2 catalysis.More practicable results were obtained with trifluoroacetic acid in the presence of cation scavengers, allowing smoothly to convert a series of 2'-methoxybenzyl ribonucleotides to the homogeneous deprotection products.

SYNTHESIS OF 2'- OR 3'-O-(4-METHOXYBENZYL)NUCLEOSIDES AND ITS APPLICATION IN THE 3'-TERMINAL NONANUCLEOTIDE SEQUENCE OF ROUS SARCOMA VIRUS 35S RNA SYNTHESIS

Kamaike, Kazuo,Tsuchiya, Hiromichi,Imai, Kazuaki,Takaku, Hiroshi

, p. 4701 - 4712 (2007/10/02)

2'- or 3'-O-(4-Methoxybenzyl)nucleoside derivatives were synthesized by treatment of uridine, N4-benzoylcytidine, N6-benzoyladenosine, and N2-benzoylguanosine with 4-methoxyphenyldiazomethane.The separation of 2'- or 3'- i

Synthesis of Ribooligonucleotides Using the 4-Methoxybenzyl Group as a New Protecting Group for the 2'-Hydroxyl Group

Takaku, Hiroshi,Kamaike, Kazuo,Tsuchiya, Hiromichi

, p. 51 - 56 (2007/10/02)

The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine, cytidine, and N2-benzoylguanosine by treatment of 2',3'-O-(dibutylstannylene)uridine or NaH-treated nucleosides with 4-methoxybenzyl bromide.The 2'-O-(4-methoxybenzyl)nucleosides can be used as useful starting materials for the synthesis of 3',5'-linked ribooligonucleotides.The 4-methoxybenzyl group was removed rapidly from the ribooligonucleotides by treatment with triphenylmethyl fluoroborate, and the completely deblocked ribooligonucleotides were characterized by enzymatic hydrolysis.

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