80016-42-8

Usage

Class

Pyrimidines

Structure

Pyrimidine ring with a chlorine atom at the 5 position and an allyloxy group at the 2 position

Uses

Organic synthesis reactions
Starting material for pharmaceuticals and agrochemicals
Building block in the synthesis of complex organic compounds

Biological and Pharmacological Activities

Antifungal properties
Antibacterial properties

Upstream product

• 22536-67-0 2,5-dichloropyrimidine 
• 20907-32-8 sodium allyloxide 
• 107-18-6 allyl alcohol 

Relevant academic research and scientific papers

Palladium Catalysis in Allylic Alkylations and Rearrangements in Pyrimidines

The regiochemistry of the alkylation of 2-pyrimidinones with ?-allylpalladium complexes from allylic acetates and Pd(0) depends on the substitution pattern in the allylic system.In Pd(II)-catalysed rearrangements of 2-propenyloxypyrimidines the preference for a 1,3-rearrangement or the Claisen 3,3-rearrangement is influenced by the substitution pattern in the allylic system.Pd(0) forms ?-allylpalladium complexes with 2-propenyloxypyrimidines which give rise to rearrangement products.The product ratios in the Pd(II) and Pd(0) rearrangements in unsymmetrically substituted allylic systems are different.The rearrangement reactions, especially the Pd(II) rearrangement, give access to products which are difficult to prepare by direct alkylation.