80022-50-0

Upstream product

• 61151-96-0 ethyl 5-methyl-2-phenyloxazole-4-carboxylate 

Downstream Products

• 80022-62-4 2-Phenyl-5-phenylsulfanylmethyl-oxazole-4-carboxylic acid 
• 80022-59-9 2-phenyl-5-phenoxymethyloxazole-4-carboxylic acid 
• 80022-68-0 2-Phenyl-10H-1-oxa-9-thia-3-aza-benzo[f]azulen-4-one 
• 80022-65-7 2-phenyl-4,10-dihydro-4-oxo<1>benzoxepino<4,3-d>oxazole 
• 80022-53-3 ethyl 2-phenyl-5-phenoxymethyloxazole-4-carboxylate 
• 80022-56-6 ethyl 2-phenyl-5-phenylthiomethyloxazole-4-carboxylate 

Relevant academic research and scientific papers

THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS

Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Chemistry of 1,2,3-Thiadiazole. IV. Synthesis of Benzoxepinothiadiazole, Benzothiepinothiadiazole, Benzothiepinothiadiazole, Benzoxepinooxazole and Benzoxepinooxazole. Four Novel Heter

Starting from the readily available 4-bromomethyl-5-carbethoxy-1,2,3-thiadiazole (V), 5-bromomethyl-4-carbethoxy-1,2,3-thiadiazole (IX) and ethyl 2-aryl-5-bromomethyloxazole-4-carboxylate (XIV), 4,10-dihydro-10-oxobenzoxepinothiadiazole (