80029-43-2

Basic information

• Product Name: 1-Hydroxybenzotriazole hydrate
• Synonyms: 1-HYDROXYBENZOTRIAZOLE N-HYDRATE;1-HYDROXYBENZOTRIAZOL MONOHYDRATE;1,2,3-BENZOTRIAZOL-1-OL MONOHYDRATE;1-HYDROXY-1,2,3-BENZOTRIAZOLE (HOBT);HOBt hydrate;1-Hydroxybenzotriazole hydrate;HOBT monohydrate (1 Hydroxybenzotriazole monohydrate);1,2,3-Benzotriazol-1-ol HOBt
• CAS NO: 80029-43-2
• Molecular Formula: 2C₆H₅N₃O*H₂O
• Molecular Weight: 153.14
• EINECS: 219-989-7
• Mol File: 80029-43-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 155-158 °C(lit.)
• Boiling Point: 344.6 °C at 760 mmHg
• Flash Point: 162.2 °C
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMF: 100 mg/mL, clear
• CAS DataBase Reference: 1-Hydroxybenzotriazole hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxybenzotriazole hydrate(80029-43-2)
• EPA Substance Registry System: 1-Hydroxybenzotriazole hydrate(80029-43-2)

Safety Data

• Hazard Codes: F
• Statements: 5-11
• Safety Statements: 15-16-35
• RIDADR: UN 3380 4.1/PG 1
• RTECS: DM1288000
• F: 4.10-8
• HazardClass: 4.1
• PackingGroup: Ⅰ
• Hazardous Substances Data: 80029-43-2(Hazardous Substances Data)

Usage

General Description

1-Hydroxybenzotriazole hydrate is a chemical compound used in organic synthesis as a coupling agent in peptide synthesis and in the synthesis of esters and amides. It is a white crystalline powder that is soluble in water and many organic solvents. The hydrate form of 1-Hydroxybenzotriazole is more stable and less prone to forming dimers compared to the anhydrous form. It is commonly used in combination with other reagents such as carbodiimides and N-hydroxy succinimide to promote amide bond formation. 1-Hydroxybenzotriazole hydrate is known for its ability to improve the efficiency and yield of peptide coupling reactions, making it a valuable tool in organic chemistry research and pharmaceutical development.

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