80033-26-7Relevant academic research and scientific papers
Benzodiazepine derivatives
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, (2008/06/13)
There are presented novel benzodiazepine derivatives of the formula STR1 wherein R1 is lower alkyl, lower hydroxyalkyl or lower dialkylaminoalkyl, R2 and R3 each are lower alkyl, R4 is halogen, R5, R
Triazolo-benzodiazepine derivatives
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, (2008/06/13)
There are presented compounds of the formula STR1 wherein R1 is a hydrogen atom or a lower alkyl group, R2 and R3 each are a hydrogen atom or a lower alkyl group, R4 is a halogen atom and either R5 is a hydrogen atom or a lower alkyl group and R6 is a lower alkyl or lower hydroxyalkyl group or R5 and R6 together with the nitrogen atom to which they are attached are a 3-membered to 7-membered heterocycle, and pharmaceutically acceptable acid addition salts thereof. The compounds and their salts are novel and possess valuable pharmacodynamic properties.
Benzodiazepine derivatives
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, (2008/06/13)
There is presented benzodiazepine derivatives of the formula STR1 wherein A is the group STR2 R1 is lower alkyl, R2 and R3 each are hydrogen or lower alkyl, R4 is the group STR3 R5 is hydrogen or halogen, R8 is hydrogen or lower alkyl, R9 is lower alkyl or lower alkoxyalkyl, R10 is lower alkyl, R11 is hydrogen, lower alkyl or lower hydroxyalkyl, R12 is hydrogen or lower alkyl and R14 is lower alkyl or aryl, and either R6 is hydrogen or lower alkyl and R7 is lower alkyl or lower hydroxyalkyl or R6 and R7 together with the nitrogen atom are a 3- to 7-membered heterocycle which, when it is at least 5-membered, can contain as a ring member an oxygen or sulphur atom or a group of the formula >N-R13, in which R13 is hydrogen or lower alkyl, and either R6 ' is hydrogen or lower alkyl and R7 ' is lower alkyl or R6 ' and R7 ' together with the nitrogen atom are a 3- to 7-membered heterocycle which, when it is at least 5-membered, can contain as a ring member an oxygen or sulphur atom or a group of the formula > N-R13 ', in which R13 ' is lower alkyl, with the proviso that R4 is the group R6 ' R7 ' N--CO--NH--CH(R8)-- when A is the group (c), and pharmaceutically acceptable acid addition salts thereof. The compounds exhibit aldosterone-antagonistic properties and are suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension.
