800366-79-4Relevant articles and documents
Glycoinsulins: Dendritic sialyloligosaccharide-displaying insulins showing a prolonged blood-sugar-lowering activity
Sato, Masaaki,Furuike, Tetsuya,Sadamoto, Reiko,Fujitani, Naoki,Nakahara, Taku,Niikura, Kenichi,Monde, Kenji,Kondo, Hirosato,Nishimura, Shin-Ichiro
, p. 14013 - 14022 (2007/10/03)
Mono-, di-, and trisialyloligosaccharides were introduced to mutant insulins through enzymatic reactions. Sugar chains were sialylated by α2,6-sialyltransferase (α2,6-SiaT) via an accessible glutamine residue at the N-terminus of the B-chain attached by t