800382-89-2Relevant academic research and scientific papers
A versatile approach to 6-substituted-5-methoxy-δ-lactam framework and application to the formal synthesis of (±)-homopumiliotoxin 223G
Chen, Bo-Fong,Tasi, Min-Ruei,Yang, Cheng-Yu,Chang, Jung-Kai,Chang, Nein-Chen
, p. 10223 - 10231 (2004)
Of the various 6-substituted-5-methoxy-δ-lactams 6 were synthesized from α-sulfonyl acetamide 9 in 4 steps in good yield. The key glutarimides 7 were obtained via facile [3+3] annulation. The method featured regioselective introduction of C-6 substituents in glutarimides 7. Synthesis of tribenzyl lactam 8 and the formal synthesis of (±)-homopumiliotoxin 223G were also reported. Graphical Abstract
