800393-58-2Relevant academic research and scientific papers
Rare Self-Luminous Mixed-Valence Eu-MOF with a Self-Enhanced Characteristic as a Near-Infrared Fluorescent ECL Probe for Nondestructive Immunodetection
Fan, Dawei,Ren, Xiang,Song, Xianzhen,Wei, Qin,Wu, Dan,Zhao, Lu
, p. 8613 - 8621 (2021)
Steady and efficient sensitized emission of Eu2+to Eu3+can be achieved through a rare mixed-valence Eu-MOF (L4EuIII2EuII). Compared with the sensitization of other substances, the similar ion radius and configuration of the extranuclear electron between Eu2+and Eu3+make sensitization easier and more efficient. The sensitization of Eu2+to Eu3+is of great assistance for the self-enhanced luminescence of L4EuIII2EuII, the longer luminous time, and the more stable electrochemiluminescence (ECL) signal. Simultaneously, L4EuIII2EuIIpossesses near-infrared (NIR) fluorescence of around 900 nm and a mighty self-luminous characteristic, which render it useful as a NIR fluorescent probe and as a luminophore to establish a NIR ECL biosensor. This NIR biosensor can greatly reduce the damage to the detected samples and even achieve a nondestructive test and improve the detection sensitivity by virtue of strong susceptibility and environmental suitability of NIR. In addition, the CeO2@Co3O4triple-shelled microspheres further enhanced the ECL intensity due to two redox pairs of Ce3+/Ce4+and Co2+/Co3+. The NIR ECL biosensor based on these strategies owns an ultrasensitive detection ability of CYFRA 21-1 with a low limit of detection of 1.70 fg/mL and also provides a novel idea for the construction of a highly effective nondestructive immunodetection biosensor.
