800401-54-1

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and properties make it a promising candidate for the synthesis of bioactive compounds, contributing to the advancement of medicinal chemistry.
Used in Medicinal Chemistry Research:
6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid is used as a subject of study in medicinal chemistry research. Its structure is of interest for understanding its potential anti-inflammatory and anti-cancer properties, which could lead to the discovery of novel therapeutic agents.
Used in Drug Development:
6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid is used as a key component in the development of drugs targeting various diseases. Its potential anti-inflammatory and anti-cancer properties make it a valuable asset in the creation of effective treatments for a range of health conditions.

InChI:InChI=1/C8H5ClN2O2/c9-7-2-1-4-5(11-7)3-6(10-4)8(12)13/h1-3,10H,(H,12,13)

Upstream product

• 800402-12-4 2-chloro-4-amino-5-iodopyridine 
• 1296201-72-3 2-chloro-5-((trimethylsilyl)ethynyl)pyridin-4-amine 
• 76-05-1 trifluoroacetic acid 
• 127-17-3 2-oxo-propionic acid 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 1296203-15-0 C₁₆H₁₄ClN₃O₂ 
• 1296200-83-3 N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide 

Relevant academic research and scientific papers

BICYCLIC HETEROARYLS AS KINASE INHIBITORS

The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Rho kinase (ROCK) inhibitors are potential therapeutic agents to treat disorders such as hypertension, multiple sclerosis, cancers, and glaucoma. Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC 50 = 1 nM) with 740-fold selectivity over PKA (47). Moreover, 47 showed very good DMPK properties making it a good candidate for further development. Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

G-PROTEIN COUPLED RECEPTOR AGONISTS

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.