800401-67-6

Basic information

• Product Name: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
• Synonyms: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate;3-c]pyridine-2-carboxylate;ethyl 5-chloro-1H-pyrrolo[2;5-Chloro-6-azaindole-2-carboxylic acid ethyl ester;5-chloro-1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester
• CAS NO: 800401-67-6
• Molecular Formula: C₁₀H₉ClN₂O₂
• Molecular Weight: 224.64
• Product Categories: CHIRAL CHEMICALS
• Mol File: 800401-67-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 405.984 °C at 760 mmHg
• Flash Point: 199.332 °C
• Appearance: /
• Density: 1.391 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.76±0.40(Predicted)
• CAS DataBase Reference: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate(800401-67-6)
• EPA Substance Registry System: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate(800401-67-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 800401-67-6(Hazardous Substances Data)

Usage

General Description

Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate is a chemical compound with the molecular formula C11H9ClN2O2. It is a pyrrole derivative with a chloro-substituted pyridine ring. ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate is commonly used in the pharmaceutical industry as a building block for the synthesis of various drug molecules. It has potential therapeutic applications due to its ability to interact with biological targets and modulate their activity. The ethyl ester group makes it more hydrophobic, which can influence its solubility and bioavailability. Further research and development are being conducted to explore its pharmacological properties and potential medical uses.

InChI:InChI=1/C10H9ClN2O2/c1-2-15-10(14)7-3-6-4-9(11)12-5-8(6)13-7/h3-5,13H,2H2,1H3

Upstream product

• 21901-40-6 2-amino-5-nitro-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 800401-66-5 ethyl-3-(2-chloro-5-nitropyridin-4-yl)-2-oxopropanoate 
• 867036-37-1 potassium (1Z)-1-(2-chloro-5-nitropyridine-4-yl)-3-ethoxy-3-oxoprop-1-en-2-olate 

Downstream Products

• 867036-42-8 (5-chloro-1H-pyrrolo[2,3-c]pyridin-2-yl)methanol 
• 800401-68-7 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 
• 867036-45-1 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxaldehyde 
• 800402-01-1 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-(S)-hydroxy-2-phenylethyl]amide 
• 800402-02-2 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-2-phenylethyl]amide 
• 800401-99-4 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [2-phenyl-1-(S)-(2-phenyl-[1,3]dioxolan-2-yl)ethyl]amide 
• 800397-99-3 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid[1-(S)-(4-fluorobenzyl)-2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]amide 
• 800398-36-1 2-(S)-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-3-phenylpropionic acid 
• 920978-86-5 ethyl 5-chloro-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 

Relevant articles and documents

Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue

Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4",3":4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).

N-(ARYLALKYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

The invention concerns compounds of general formula (I), wherein n, the pyrrolopyridine ring, X, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. The invention also concerns a method for preparing said compounds and their therapeutic use.

G-PROTEIN COUPLED RECEPTOR AGONISTS

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.