800407-10-7

Upstream product

• 247144-48-5 (E)-3-((2R,3R,4R,5S)-3-Benzyloxy-4,5-dihydroxy-tetrahydro-furan-2-yl)-acrylic acid ethyl ester 
• 108788-49-4 ethyl (E)-[3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-α-D-gluco]-heptofuran-5-en-uronate 
• 100-46-9 benzylamine 

Downstream Products

• 687992-26-3 1,4,5-trideoxy-1,4-imino-D-arabino-hexitol 
• 543690-37-5 (1R,2R,7aR)-(+)-1,2-dihydroxypyrrolizidine 
• 125279-72-3 (1R,2R,8aR)-lentiginosine 
• 893403-08-2 ((2R,3R,4R)-1-Benzyl-4-benzyloxy-3-trimethylsilanyloxy-pyrrolidin-2-yl)-acetaldehyde 
• 893403-04-8 methyl 3-((2R,3R,4R)-1-benzyl-4-benzyloxy-3-hydroxypyrrolidin-2-yl)propanoate 
• 893402-90-9 ethyl 2-((2R,3R,4R)-1-benzyl-4-benzyloxy-3-trimethylsilyloxypyrrolidin-2-yl)acetate 

Relevant academic research and scientific papers

The intramolecular conjugate addition of benzylamine to a D-glucose derived α,β-unsaturated ester: An efficient synthesis of trihydroxylated pyrrolidine alkaloids as potential glycosidase inhibitors

A short and efficient synthesis of 1,4,5-trideoxy-1,4-imino-l-xylo-hexitol 2a and 1,4,5-trideoxy-1,4-imino-d-arabino-hexitol 2b is reported using the intramolecular conjugate addition of in situ generated benzylamine to the α,β-unsaturated ester 4, derived from d-glucose, as the key step.