80041-89-0

Usage

Uses

Used in Chemical Synthesis:
Isopropylboronic acid is used as a reagent in various chemical reactions for the synthesis of complex organic molecules. Its ability to form stable boron-containing intermediates makes it a valuable component in the development of new synthetic routes.
Used in Copper-Promoted Cross-Coupling Reactions:
Isopropylboronic acid is employed as a reagent in copper-promoted cross-coupling reactions, which are widely used in the formation of carbon-carbon bonds. This application allows for the efficient synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Domino Heck-Suzuki Reactions:
Isopropylboronic acid is used as a reagent in domino Heck-Suzuki reactions, which are a series of consecutive reactions that lead to the formation of complex organic structures. This application enables the rapid assembly of diverse molecular frameworks, facilitating the discovery of new bioactive compounds.
Used in Suzuki-Miyaura Type Couple Reactions:
Isopropylboronic acid is used as a reagent in Suzuki-Miyaura type couple reactions, which are a class of palladium-catalyzed cross-coupling reactions. This application allows for the formation of carbon-carbon bonds between aryl and alkyl halides, providing a powerful tool for the synthesis of various organic compounds.
Used in Alkylation-Hydride Reduction Sequence:
Isopropylboronic acid is used as a reagent in alkylation-hydride reduction sequences, which involve the introduction of an alkyl group followed by a reduction step. This application enables the selective formation of specific functional groups, broadening the scope of organic synthesis.

InChI:InChI=1/C3H9BO2/c1-3(2)4(5)6/h3,5-6H,1-2H3

Upstream product

• 688-74-4 boric acid tributyl ester 
• 920-39-8 isopropylmagnesium bromide 
• 60-29-7 diethyl ether 
• 150-46-9 triethyl borate 
• 1068-55-9 isopropylmagnesium chloride 
• 7732-18-5 water 
• 76347-13-2 2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 66740-05-4 tri(isopropyl)boroxine 
• 119246-82-1 2-isopropyl-[1,3,6,2]dioxazaborocane 
• 770-40-1 N-(4-chlorophenyl)-N-isopropylamine 
• 16495-67-3 4-(isopropylamino)anisole 
• 76347-13-2 2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 22105-89-1 5-(iso-propyl)-3-methyl-1-benzothiophene 
• 4706-89-2 2,4-dimethylcumene 
• 1817-47-6 4-nitrocumene 
• 166963-93-5 1-(4-(iso-propyl)phenyl)-1H-pyrrole 
• 135-79-5 6-isopropylquinoline 
• 6380-20-7 3-isopropylanisole 
• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 7205-61-0 1-methoxy-4-<(1-methylethyl)thio>-benzene 
• 344396-19-6 3,5-dimethoxy-4-(1-methylethyl)benzaldehyde 

Relevant academic research and scientific papers

A General C(sp3)-C(sp3) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids

A general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and 1°, 2°, or 3° alkyl boronic acids is reported. The base-promoted reaction is operationally simple and exhibits a broad substrate scope to forge a variety of alkyl-alkyl bonds, including between sterically encumbered secondary and tertiary sp3-carbons. The ability of this method to simplify retrosynthetic analysis is exemplified by the improved synthesis of multiple medicinally relevant scaffolds.

Organotrifluoroborate hydrolysis: Boronic acid release mechanism and an acid-base paradox in cross-coupling

The hydrolysis of potassium organotrifluoroborate (RBF3K) reagents to the corresponding boronic acids (RB(OH)2) has been studied in the context of their application in Suzuki-Miyaura coupling. The "slow release" strategy in such SM couplings is only viable if there is an appropriate gearing of the hydrolysis rate of the RBF3K reagent with the rate of catalytic turnover. In such cases, the boronic acid RB(OH)2 does not substantially accumulate, thereby minimizing side reactions such as oxidative homocoupling and protodeboronation. The study reveals that the hydrolysis rates (THF, H2O, Cs2CO 3, 55 °C) depend on a number of variables, resulting in complex solvolytic profiles with some RBF3K reagents. For example, those based on p-F-phenyl, naphthyl, furyl, and benzyl moieties are found to require acid catalysis for efficient hydrolysis. This acid-base paradox assures their slow hydrolysis under basic Suzuki-Miyaura coupling conditions. However, partial phase-splitting of the THF/H2O induced by the Cs2CO 3, resulting in a lower pH in the bulk medium, causes the reaction vessel shape, material, size, and stirring rate to have a profound impact on the hydrolysis profile. In contrast, reagents bearing, for example, isopropyl, β-styryl, and anisyl moieties undergo efficient "direct" hydrolysis, resulting in fast release of the boronic acid while reagents bearing, for example, alkynyl or nitrophenyl moieties, hydrolyze extremely slowly. Analysis of B-F bond lengths (DFT) in the intermediate difluoroborane, or the Swain-Lupton resonance parameter (R) of the R group in RBF3K, allows an a priori evaluation of whether an RBF3K reagent will likely engender "fast", "slow", or "very slow" hydrolysis. An exception to this correlation was found with vinyl-BF 3K, this reagent being sufficiently hydrophilic to partition substantially into the predominantly aqueous minor biphase, where it is rapidly hydrolyzed.

Tripeptidylpeptidase inhibitors

A compound of formula wherein the substituents are defined as in the specification and salts or hydrates thereof is disclosed as well as a method of treating disorders associated with the inactivation or excessive degradation of cholecystokinin.