80050-38-0Relevant academic research and scientific papers
Synthesis of functionalized pyrazole derivatives by regioselective [3+2] cycloadditions of N-Boc-α-amino acid-derived ynones
Kirar, Eva Pu?avec,Gro?elj, Uro?,Golobi?, Amalija,Poagan, Franc,Ri?ko, Sebastijan,?tefane, Bogdan,Svete, Jurij
, p. 467 - 480 (2018/06/18)
[3+2] cycloadditions of ynones derived from glycine and (S)-alanine and some other dipolarophiles with azomethine imines, nitrile oxides, diazoacetate, and azidoacetate were studied. The dipolarophiles were obtained from α-amino acids, either by the reduc
Double transfer of chirality in organocopper-mediated bis(alkylating) cycloisomerization of enediynes
Campolo, Damien,Arif, Tanzeel,Borie, Cyril,Mouysset, Dominique,Vanthuyne, Nicolas,Naubron, Jean-Valere,Bertrand, Michele P.,Nechab, Malek
supporting information, p. 3227 - 3231 (2014/04/03)
An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo-, regio-, diastereo-, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central-to-axial-to- central) is observed. Double duty: An original synthesis of chiral benzofulvenes was developed through the highly chemo-, regio-, diastereo-, and enantioselective double transfer of alkyl groups to electrophilic enediynes. This organocopper-triggered cycloisomerization proceeds with double transfer of chirality (central-to-axial-to-central).
