80054-63-3

Usage

Type of compound

Organic compound

Category

Fatty acid derivative

Common uses

Cosmetics and personal care industry as an emollient and skin conditioning agent

Physical state

Clear, colorless liquid

Odor

Mild

Properties

Moisturizing and softening

Applications

Skincare products (lotions, creams, lip balms), hair care products (conditioning and smoothing effects)

Benefits

Improves texture and appearance of skin, provides conditioning and smoothing effects for hair

Industry

Beauty and personal care industry

InChI:InChI=1/C14H28O3/c1-2-11-14(16)17-13-10-8-6-4-3-5-7-9-12-15/h15H,2-13H2,1H3

Upstream product

• 112-47-0 1,10-Decanediol 
• 141-75-3 butyryl chloride 

Relevant academic research and scientific papers

Synthesis and SAR studies of neuritogenic gentiside derivatives

Tetradecyl 2,3-dihydroxybenzoate (ABG-001) has been designed and synthesised as a lead compound to treat Alzheimer's disease, based on structure-activity relationships of gentisides. In this paper, the alkyl chain and ester linkage group of ABG-001 were modified. Consequently, several series of novel gentiside derivatives were designed and synthesised, and their neuritogenic activity was evaluated in PC12 cells. Among all the tested compounds, S-dodecyl 2,3-dihydroxybenzothioate (15d, named as ABG-199) was the most potent; the compound induced significant neurite outgrowth at 0.1 μM, which was comparable to that of nerve growth factor at the optimal concentration of 40 ng/mL and ABG-001 at 1 μM. A brief study on the mechanism of action of ABG-199 revealed that extracellular signal-regulated kinase phosphorylation was involved in ABG-199-induced neurite outgrowth in PC12 cells.