80055-36-3

Upstream product

• 80124-29-4 ((3S,5S,8S,10S,13R,14S,16R,17S)-3-Hydroxy-10,13,16-trimethyl-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-acetic acid methyl ester 
• 80055-34-1 [(3S,5S,8S,10S,13R,14S,16R,17S)-10,13,16-Trimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-acetic acid methyl ester 
• 80055-30-7 3β-hydroxy-16α-methyl-5α-pregn-9(11)-en-21-oic acid 
• 110-87-2 3,4-dihydro-2H-pyran 
• 80055-35-2 2-[(3S,5S,8S,10S,13R,14S,16R,17S)-10,13,16-Trimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Alkylated Steroids. Part 4. An Unusual Favorskii Rearrangement

Favorskii rearrangement of the mixed 17ξ-bromo-16α-methyl-20-oxo-5α-pregn-9(11)-en-3β-yl acetates (5) and (6) (9:1) gives methyl 3β-hydroxy-16α,17α-dimethyl-5α-androst-9(11)-ene-17-carboxylate (7) and methyl 3β-hydroxy-16α-methyl-5α-pregn-9(11)-en-21-oate (9) as the major components.Only a small amount of the isomeric 16α,17β-dimethyl-17-carboxylate (8) is formed.The structures of the esters (7) and (9) are confirmed by synthesis, and an explanation for the unexpected formation of (9) is advanced.