80079-63-6Relevant academic research and scientific papers
Molecular design and structure - Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
Das, Jagabandhu,Kimball,Hall, Steven E.,Han, Wen-Ching,Iwanowicz, Edwin,Lin, James,Moquin, Robert V.,Reid, Joyce A.,Sack, John S.,Malley, Mary F.,Chang, Chiehying Y.,Chong, Saeho,Wang-Iverson, David B.,Roberts, Daniel G.M.,Seiler, Steven M.,Schumacher, William A.,Ogletree, Martin L.
, p. 45 - 49 (2007/10/03)
A series of structurally novel small molecule inhibitors of human α-thrombin was prepared to elucidate their structure-activity relationships (SARs), selectivity and activity in vivo. BMS-189664 (3) is identified as a potent, selective, and orally active reversible inhibitor of human α-thrombin which is efficacious in vivo in a mouse lethality model, and at inhibiting both arterial and venous thrombosis in cynomolgus monkey models.
