80081-06-7

Basic information

• Product Name: LewisBtetrasaccharide
• Synonyms: alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-beta-D-GlcpNAc;N-[(3R,4R,5S,6R)-4-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2-hydroxy-6-(hydroxymethyl)-5-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]acetamide
• CAS NO: 80081-06-7
• Molecular Formula: C26H45NO19
• Molecular Weight: 675.63
• Mol File: 80081-06-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: LewisBtetrasaccharide(CAS DataBase Reference)
• NIST Chemistry Reference: LewisBtetrasaccharide(80081-06-7)
• EPA Substance Registry System: LewisBtetrasaccharide(80081-06-7)

Safety Data

• Hazardous Substances Data: 80081-06-7(Hazardous Substances Data)

Usage

General Description

LewisB tetrasaccharide is a complex carbohydrate composed of four sugar units: two N-acetylglucosamine molecules and two galactose molecules. It is a blood group antigen found on the surface of red blood cells and plays a role in cell-cell recognition and adhesion. LewisB tetrasaccharide is important in immune responses and inflammation, as it can influence the interactions between cells and proteins in the immune system. In addition, LewisB tetrasaccharide has been implicated in various physiological and pathological processes, including cancer metastasis, viral infections, and autoimmune diseases. Understanding the functions and properties of LewisB tetrasaccharide can provide insight into its potential as a therapeutic target for treating various diseases.

Upstream product

• 80035-26-3 benzyl 2-acetamido-2-deoxy-4-O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-3-O-<2-O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-β-D-galactopyranosyl>-β-D-glucopyranoside 

Relevant articles and documents

The chemical synthesis of O-alpha-L-fucopyranosyl-(1 goes to 2)-O-beta-D-galactopyranosyl-(1 goes to 3)-O-[alpha-L-fucopyranosyl-(1 goes to 4)]-2-acetamido-2-deoxy-D-glucopyranose, the Lewis b blood-group antigenic determinant.

An approach has been developed for the rapid synthesis of benzyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-beta-D-glucopyranoside (5). Disaccharide 5 was per(trimethylsilyl)ated, to provide the fully protected trimethylsilyl (Me3Si) derivative which