80083-18-7Relevant academic research and scientific papers
Synthesis and the Crystal Structure of 4-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-methyl-1,2,4-triazin-3(4H)-one 1-Oxide, a Structural Analogue of Thymidine
Bobek, M.,Glowka, M.,Parthasarathy, R.
, p. 913 - 916 (2007/10/02)
Condensation of pyruvaldehyde dimethyl acetal with thiosemicarbazide, followed by methylation and cyclization, gave 3-(methylthio)-6-methyl-1,2,4-triazine, which was converted to 6-methyl-1,2,4-triazin-3(4H)-one 1-oxide by treatment with sodium methoxide and by selective oxidation and hydrolysis.Following silylation, this intermediate was condensed with blocked 2-deoxyribofuranosyl chloride, providing the anomeric nucleoside mixture, which was separated and deblocked to furnish the title compound.X-ray analysis of this nucleoside was carried out to confirm its structure and to study its conformation.
