80092-48-4

Basic information

• Product Name: 9(2H)-Acridinone, 1-[[3-(butylamino)propyl]imino]-7-chloro-3-(3,4-dichlorophenyl)-1,3,4,10 -tetrahydro-10-hydroxy-
• CAS NO: 80092-48-4
• Molecular Formula: C26H28Cl3N3O2
• Molecular Weight: 520.886
• Mol File: 80092-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9(2H)-Acridinone, 1-[[3-(butylamino)propyl]imino]-7-chloro-3-(3,4-dichlorophenyl)-1,3,4,10 -tetrahydro-10-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 9(2H)-Acridinone, 1-[[3-(butylamino)propyl]imino]-7-chloro-3-(3,4-dichlorophenyl)-1,3,4,10 -tetrahydro-10-hydroxy-(80092-48-4)
• EPA Substance Registry System: 9(2H)-Acridinone, 1-[[3-(butylamino)propyl]imino]-7-chloro-3-(3,4-dichlorophenyl)-1,3,4,10 -tetrahydro-10-hydroxy-(80092-48-4)

Safety Data

• Hazardous Substances Data: 80092-48-4(Hazardous Substances Data)

Upstream product

• 75618-33-6 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione 
• 6935-60-0 N-(3-aminopropyl)butylamine 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.